Coleus Forskholii
The basic mechanism of action of Coleus is the activation of an enzyme, adenylate cyclase, which increases the amount of cyclic adenosine monophosphate (cAMP) in cells. Cyclic AMP is perhaps the most important cell regulating compound. Once formed it activates many other enzymes involved in diverse cellular functions.
The effects of raised cAMP include: inhibition of mast cell degranulation and histamine release, inhibition of platelet activation and degranulation, increased force of contraction of heart muscle, relaxation of the arteries and other smooth muscles, increased insulin secretion, increased thyroid function, and increased lypolysis (fat breakdown). Note: smooth muscle refers to the tissue found in the bronchials, GI tract, uterus, bladder and arteries.
- ANTI-ALLERGIC – Conditions such as eczema and asthma are characterised by a relative decrease in cAMP in the skin and bronchial smooth muscle, respectively. The effect of this causes mast cell degranulation and smooth muscle contraction along with excessive levels of platelet activating factor (PAF). PAF plays a central role in many inflammatory and allergic responses including bronchoconstriction and reduced coronary blood flow. Most modern drugs for allergic symptoms are designed to increase cAMP levels. Coleus achieves this through improving enzyme activity without negative side effects.
- SKIN CELL REGULATOR – Psoriasis is a common skin disorder believed to be caused by a decrease in cAMP in relation to another cell-regulating substance, cyclic guanine monophosphate (cGMP). The result of this is a dramatic increase in cell division (1000 times the normal level). Studies have indicated that Coleus may be very useful for psoriasis sufferers because of its balancing effect on cAMP and cGMP.
- CARDIOVASCULAR SUPPORT – One of the most beneficial aspects of Coleus appears to be relating to its use in conditions such as hypertension, congestive heart failure, and angina. Coleus has been shown to reduce blood pressure along with improving the contractility of the heart. This improvement in function appears to be mainly due to the increase in cAMP. Coleus is also noted for its effects on reducing platelet aggregation and acting as a direct cerebral vasodilator.
- WEIGHT CONTROL / HYPOTHYROIDISM – Coleus may offer benefit through regulating lypolysis (breakdown of stored fat) and increasing thyroid hormone production and release.
- MALABSORPTION AND DIGESTIVE DISORDERS – Coleus stimulates digestive secretions i.e. HCL, pepsin, amylase and pancreatic enzymes. Coleus has also demonstrated effects in improving nutrient absorption in the small intestine as well as improving the release of salivary amylase (helpful in cases of dry mouth).
Viridian Coleus Forskholii
Dosage: 50mg two to three times daily, standardised to contain 10 percent forskolin.
Ingredients: one vegetarian capsule provides:
Coleus Forskholii Root Powder - 200mg
Standardised Coleus Forskhlii Root Extract (10% forskholin) - 100mg
Viridian bilberry extract, organic alfalfa, organic spirulina blend - 50mg
Potential applications: Eczema / Psoriasis, cardiovascular disease, respiratory disorders, allergic conditions, glaucoma, weight control, IBS, dry mouth syndrome, immune enhancement
Known contraindications: Caution suggested in those with peptic ulcer or hypotension
Interactions: Caution in those taking anti-coagulant, antihypertensive, and antiasthmatic medication as it may potentiate the effects of these drugs.
Useful links: May be particularly useful in combination with Hawthorn in some cases. Other links include milk thistle, digestive enzymes, quercetin, flax/hemp seed oil.
Viridian Coleus Forskholii - 90 Veg Caps - £20.45
30 veg caps - £8.35
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Disclaimer: All information contained on this website is for information only and should not be used to diagnose, prevent, treat or cure any disease, health or medical condition. The products (food supplements) are not intended to diagnose, prevent, treat or cure any health or medical condition. Do not exceed stated dose or use with prescribed medication unless advised by a doctor or medical practitioner. Do not take if pregnant or lactating. Keep out of reach of children. Consult doctor for all medical advice.
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